Riders heading east on La Trobe Street will be detoured for a week from this Friday, 13 March.
A major crane installation at the State Library Station site will close the Street to all east bound traffic.
Riders will be directed to take the same detour as has been used previously when construction works has necessitated the closure La Trobe Street.
That detour is down Queens Street, then along Little Lonsdale Street to Russell Street, and back to La Trobe.
The detour kicks in at 8pm on Friday 13 March, and is in place until 8pm on Friday 20 March, 2020.
West-bound traffic will operate as usual.
The works involve constructing a base slab using concrete pumps and trucks, installing a gantry upon which the tower crane will be mounted on, and mobilising a supporting crane to install the tower crane at the La Trobe Street site using heavy vehicles, light towers and hand tools.
The tower crane will be located on the southern side of the site and will be in place for approximately three years.
Little La Trobe Street will be closed from Swanston Street to motorists, cyclists and pedestrians during the assembly of the crane boom, which is on the final day of the La Trobe Street eastbound lane closure.